The impact of tumor microenvironment and treatment schedule on the effectiveness of radiation therapy.

ABSTRACT: External Beam Radiation Therapy (EBRT) is predominantly administered using Conventionally Fractionated Radiotherapy (CFRT), that is 2 Gy per fraction. However, Moderately Hypofractionated Radiotherapy (MHRT) (approx. 2.5-3 Gy per fraction) and Stereotactic Body Radiotherapy (SBRT) (approx. 6-24 Gy per fraction) regimen are currently clinically investigated or even recently included in standard clinical practice. In addition, hyperfractionated radiotherapy (<1.8-2 Gy per fraction) is also clinically investigated or already used in standard clinical practices. The therapeutic effects of each of these radiotherapy schedules might depend on the degree of radioresistance of the tumor but also on properties of the tumor microenvironment, such as tumor perfusion and oxygenation. Here, building on

SUBMITTER: Dimou K 

PROVIDER: S-EPMC12443294 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature