Iron-saturated bovine lactoferrin preserves microbiota diversity and healthy ageing-associated taxa in an in vitro colon model of elderly gut microbiota (Iron-saturated bovine lactoferrin impact on elderly gut microbiota).

ABSTRACT: Lactoferrin is a multifunctional milk protein receiving increased interest in recent years because of its potential as a functional food ingredient to reduce the prevalence of iron deficiency, while providing additional health benefits including gut microbiota modulation. Iron deficiency represents one of the most prevalent micronutrient deficiencies globally. As such, the aims of this study were (1) to assess the effect of lactoferrin, with different states of iron saturation, on the growth of a simple consortium of gut bacteria, and (2) to evaluate the impact of iron-saturated lactoferrin on the whole gut microbiome of elderly (healthy and frail) donors in an in vitro colon model. We report that iron-depleted and native lactoferrin inhibited consortium growth, while the iron-saturated fo

SUBMITTER: Ruiz-Rico M 

PROVIDER: S-EPMC12443303 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature