Predictive value of SOFA, PCT, Lactate, qSOFA and their combinations for mortality in patients with sepsis: A systematic review and meta-analysis.

ABSTRACT:

Background

Sepsis is a leading cause of death, necessitating early prediction of mortality risk.

Objective

To systematically review the predictive efficacy of the Sequential Organ Failure Assessment (SOFA), procalcitonin (PCT), lactate, quick Sequential Organ Failure Assessment (qSOFA), and lactate-adjusted qSOFA (LqSOFA) for the risk of death in patients with sepsis.

Methods

According to PRISMA-DTA guidelines, PubMed, Embase, the Cochrane Library, and CNKI were searched (up to March 2025), and 29 studies were included (n = 41,469). A bivariate random-effects model was used to pool the sensitivity, specificity, diagnostic odds ratio, and area under the receiver operating characteristic curve (AUROC). The ΔAUROC was compared using a random-effects model based on a pair

SUBMITTER: Lu J 

PROVIDER: S-EPMC12443322 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature