Herbomineral Medicine Peedanil Gold Exerts Analgesia in Neuropathy by Moderating Inflammatory Response and TRP Channel Expression in Sprague Dawley Rat Surgical Chronic Constriction Injury Model.

ABSTRACT: Background: Chronic neuropathic pain, a debilitating health condition, significantly deteriorates the quality of life. Available treatment options, mostly focusing on pain management, do not target underlying cause, resulting in suboptimal and temporary outcomes. Therefore, therapeutic targeting of the cause of neuropathic pain is necessary. This study was undertaken to assess the antineuropathic potential of the herbomineral formulation, Peedanil Gold (PN-G), which has earlier been proven effective against osteoarthritis and associated inflammatory pathophysiology. Methods: Unilateral sciatic nerve chronic constriction injury (CCI) rat model was used to assess the analgesic and anti-inflammatory potential of PN-G in managing chronic neuropathy and associated pain hypersensit

SUBMITTER: Balkrishna A 

PROVIDER: S-EPMC12443517 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature