An implantable system to restore hemodynamic stability after spinal cord injury.

ABSTRACT: A spinal cord injury (SCI) causes immediate and sustained hemodynamic instability that threatens neurological recovery and impacts quality of life. Here we establish the clinical burden of chronic hypotensive complications due to SCI in 1,479 participants and expose the ineffective treatment of these complications with conservative measures. To address this clinical burden, we developed a purpose-built implantable system based on biomimetic epidural electrical stimulation (EES) of the spinal cord that immediately triggered robust pressor responses. The system durably reduced the severity of hypotensive complications in people with SCI, removed the necessity for conservative treatments, improved quality of life and enabled superior engagement in activities of daily living. Central to the de

SUBMITTER: Phillips AA 

PROVIDER: S-EPMC12443590 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature