Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques.

ABSTRACT: Antler blastema progenitor cells (ABPCs) are a distinct population of skeletal mesenchymal stem cells found in regenerating deer antlers, with strong stemness and renewal capacity in vitro. Stem cell-derived extracellular vesicles (EVs) are emerging as potential therapeutic candidates that can mediate donor cells' beneficial effects. Here, we tested the effects of ABPC-derived EVs (EVs^ABPC) on aging in mice and rhesus macaques (Macaca mulatta). We identified a variety of unique factors in EVs^ABPC and showed that in vitro, EVs^ABPC attenuated phenotypes of senescence in bone marrow stem cells. In aged mice and macaques, EVs^ABPC substantially increased femoral bone mineral density. Further, intravenous EVs^ABPC improved physical performanc

SUBMITTER: Hao Y 

PROVIDER: S-EPMC12443635 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature