Antibacterial, antibiofilm and cytotoxic activity of synthesized metal-incorporated mesoporous silica nanoparticles.

ABSTRACT: Antibiotic misuse has triggered a global health crisis due to the rise of antimicrobial-resistant microorganisms. Recent studies suggest that nanoparticles (NPs), particularly silver nanoparticles, may provide a solution. However, their toxicity necessitates the development of novel carriers to enhance targeting while minimizing cytotoxicity. This study aimed to synthesize, characterize mesoporous silica nanoparticles (MSN) incorporated with silver alone or combined with zinc, and evaluate their antibacterial, antibiofilm, and cytotoxic properties. Characterization through X-ray diffraction (XRD) and scanning electron microscopy (SEM), revealed particle sizes between 413 and 560 nm. Antibacterial activity was assessed via the broth-dilution method against Staphylococcus aureus ATCC 25,923,

SUBMITTER: Shehata S 

PROVIDER: S-EPMC12443651 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature