In ovo model with emu eggs as novel alternative to animal testing in preclinical imaging research.

ABSTRACT:

Background

Large-size in ovo models are receiving increasing attention since they comply with the 3R requirements (Replacement, Reduction and Refinement) by limiting the number of fully developed laboratory animals. In preclinical imaging research, a specific advantage is that they do not require dedicated scanners for small animals (expensive and rarely available) but are suitable for imaging studies by scanners used for clinical examinations. The present study evaluated large-sized fertilized emu eggs as a candidate model for preclinical imaging research in nuclear medicine by [¹⁸F]FDG-PET/CT, aiming to increase the repertoire of alternative models to conventional animal testing.

Results

Of 31 fertilized eggs, 18 eggs had viable peripheral vasculature available

SUBMITTER: Perkas O 

PROVIDER: S-EPMC12443669 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature