Kuntai Capsules Improve Premature Ovarian Failure by Regulating AMPK-Mediated Autophagy.

ABSTRACT:

Background

Premature ovarian failure (POF) is a gynecological endocrine disorder with current treatments having limitations. Kuntai capsule (KTC), a traditional Chinese medicine formulation, is thought to be beneficial for POF, but its mechanism is unclear. Network pharmacology can help explore drug mechanisms.

Methods

A POF rat model was established using cyclophosphamide (CTX). Rats received low-dose KTC (0.6 g/kg/d), high-dose KTC (1.8 g/kg/d), or dehydroepiandrosterone (DHEA, positive control). Ovarian function was evaluated via histopathology, hormone assays (ELISA), apoptosis (TUNEL/flow cytometry), autophagy markers (Western blot), and network pharmacology.

Results

KTC treatment (especially high-dose) ameliorated POF in CTX-treated rats, as shown by increased o

SUBMITTER: Ye X 

PROVIDER: S-EPMC12443895 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature