Parallel Offline Breath Sampling for Cross-Validated Analysis of Volatile Organic Compound Metabolites.

ABSTRACT:

Introduction

Volatile organic compounds (VOCs) in breath are potential biomarkers for medical conditions that may be used for non-invasive health monitoring. One challenge that still exists is determining the fidelity of reported VOC biomarkers. The lack of universally accepted sampling methods makes it difficult to identify reliable candidates, thus allowing for the potential of false discovery.

Objectives

The purpose of this study was to robustly profile VOCs in breath samples collected from relatively healthy participants using two offline methods for collection/analysis via solid phase microextraction (SPME) coupled to gas chromatography - mass spectrometry (GC-MS).

Methods

158 cross-sectional volunteers provided one-time samples using two methods, one which direc

SUBMITTER: Schulz E 

PROVIDER: S-EPMC12443928 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature