Production of human papillomavirus type 16 virus-like particles in Physcomitrella photobioreactors.

ABSTRACT:

Key message

First production of virus-like particles as a vaccine candidate in a non-vascular plant. Virus-like particles (VLPs) are self-assembling nanoparticles composed of viral structural proteins which mimic native virions but lack viral DNA and infectivity. VLPs are a resourceful class of biopharmaceuticals applied as subunit vaccines or as delivery vehicles for drugs and nucleic acids. Similar to viruses, VLPs are diverse in structure, composition, and assembly, requiring a tailored production platform aligned with the intended application. The moss plant Physcomitrella (Physcomitrium patens) is an emerging expression system offering humanized N-glycosylation, scalability, and adaptability to existing industry settings. Here, we used Physcomitrella to produce human papilloma

SUBMITTER: Niederau PA 

PROVIDER: S-EPMC12443937 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature