The influence of morphine treatment on the opioid propeptide gene expression in the forebrain of two inbred mouse strains with different sensitivity to opioids.

ABSTRACT:

Background

C57BL/6 and DBA/2 mouse strains differ markedly in behavioral responses to acute and chronic morphine administration. Some of these disparities might be underlain by and/or correlated with different expression of the opioid propeptide genes Pdyn and Penk. The objective of our study was to characterize the influence of morphine on Pdyn and Penk expression in substance abuse-related forebrain regions of C57BL/6 and DBA/2 mice.

Methods

Pdyn and Penk mRNA levels were measured using in situ hybridization after acute or chronic morphine administration, and during 24-48-h withdrawal.

Results

Pdyn and Penk gene expression was increased after chronic morphine and throughout withdrawal in all investigated brain regions. The changes were strain-specific in the central

SUBMITTER: Ziolkowska B 

PROVIDER: S-EPMC12443941 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature