Differential effects of hemodialysis modalities on circulating neutrophil extracellular traps in children on maintenance hemodialysis: a cohort study.

ABSTRACT: Flow of blood through the extracorporeal circuit during conventional hemodialysis (HD) can induce neutrophil activation, leading to inflammatory and cytokine responses. So, we evaluated the effect of modality and membrane performance of dialysis session in children on maintenance HD on neutrophil activation by measuring the level of circulating neutrophil extracellular traps (NETs). Twenty-six incident children stable on LFHD for at least 3 months were recruited along with 26 age- and sex-matched healthy controls. Pre-and post-session blood samples for complete blood count (CBC), C - reactive protein (CRP), and NETs were obtained on a mid-week session. Patients were shifted to HFHD for 3 months, followed by post-dilutional OL-HDF for additional 3 months. Blood tests were repeated at the en

SUBMITTER: Kasem MF 

PROVIDER: S-EPMC12443955 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature