Phenotyping and characterising gait profiles of people with multiple sclerosis.

ABSTRACT: Gait disorders are among the most disabling symptoms in people with multiple sclerosis (pwMS), substantially affecting quality of life, autonomy, and participation. The Expanded Disability Status Scale (EDSS) captures impairments -particularly pyramidal, cerebellar and sensory- that influence gait patterns. Quantitative gait analysis enables objective exploration of these patterns supporting personalised strategies. This study aimed to characterise gait profiles in pwMS based on EDSS-derived functional scores. In this cross-sectional study at University Hospital Dresden, 204 pwMS and 237 healthy controls underwent instrumented gait assessments under self-selected, fast, and dual-task conditions. PwMS were categorised into pyramidal, cerebellar, or sensory gait pattern groups based on EDSS

SUBMITTER: Trentzsch K 

PROVIDER: S-EPMC12443981 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature