Reversion of aortic valve cells calcification by activation of Notch signalling via histone acetylation induction.

ABSTRACT: Calcification of the aortic valve is a prevalent cardiovascular pathology in the aging population. Traditionally linked to inflammation, lipid accumulation, and risk conditions, this disease remains poorly understood, and effective treatments to halt its progression are not yet available. We hypothesized that calcification of the human valve interstitial cells (VICs) is associated with cellular senescence and alterations in the epigenetic setup, like in arteries. To verify this hypothesis, we examined the epigenetic marks (DNA methylation; Histones H3/H4 acetylation/methylation), the senescence and the calcification process in human VICs obtained from two distinct pathologic settings of the aortic valve (valve insufficiency and valve stenosis), and employed a mouse model of vascular/valve

SUBMITTER: Garoffolo G 

PROVIDER: S-EPMC12443999 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature