Nocturnal hypoxemia in COPD: the amplifying effect of comorbid OSA and PLMS on oxygen desaturation.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD), obstructive sleep apnea (OSA), and periodic limb movements of sleep (PLMS) frequently co-occur and may exacerbate nocturnal hypoxemia. Still, their combined effects are not well defined.

Objectives

To examine the independent and interactive effects of COPD, OSA, and PLMS on nocturnal oxygen desaturation.

Design

Cross-sectional analysis of a sleep study cohort.

Methods

We analyzed 711 participants (mean age 57.2 ± 17.9 years; 44.4% male), including 48 with COPD. Time with oxygen saturation ⩽88% (ST) and mean SpO₂ were compared across COPD and OSA/PLMS subgroups. Multivariable regression tested the independent and interaction effects of COPD, OSA, PLMS, age, and sex.

Results

Participants w

SUBMITTER: Jain V 

PROVIDER: S-EPMC12444068 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature