Comparative validation of low-density lipoprotein cholesterol estimation formulas in older Georgian adults.

ABSTRACT:

Introduction

Low-density lipoprotein cholesterol (LDL-C) is a critical marker for cardiovascular risk assessment. Although direct measurement offers high accuracy, it is often cost-prohibitive and impractical for routine use in low- and middle-income countries. Multiple formulas, including those by Friedewald, de Cordova, and Chen, have been proposed to estimate LDL-C, though their accuracy varies across populations. This study evaluated the performance of eight LDL-C estimation formulas against direct measurement in a predominantly older adult Georgian cohort.

Materials and methods

We retrospectively analyzed lipid profiles from 500 adults with complete panels, stratified by triglyceride (TG) levels, high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and

SUBMITTER: Nino G 

PROVIDER: S-EPMC12444148 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature