Association between tacrolimus blood levels and biopsy-proven acute cellular rejection in adult heart transplant recipients.

ABSTRACT:

Background

Acute cellular rejection (ACR) is a common complication following heart transplantation (HTx). This study examined the association between tacrolimus whole-blood concentrations and endomyocardial biopsy (EMB)-proven ACR in adult HTx recipients.

Methods

We conducted a retrospective analysis of 41 adult HTx recipients enrolled in the HEARTBiT study at St. Paul's Hospital (Vancouver, Canada) between August 2018 and February 2020. A total of 315 EMB visits were analyzed and matched with tacrolimus whole-blood trough concentrations measured within ±1 day using liquid chromatography-tandem mass spectrometry. Patients were stratified into 2 post-transplant intervals: 0 to 90 days and 91 to 180 days, based on BC Clinical Guidelines for Transplant Medications for target ta

SUBMITTER: Yang C 

PROVIDER: S-EPMC12444152 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature