Lipid metabolism of clear cell renal cell carcinoma predicts survival and affects intratumoral CD8 T cells.

ABSTRACT:

Background

Clear cell renal cell carcinoma (ccRCC), the most common RCC subtype, both accumulates and depletes selected lipid species. However, the prognostic role of lipid metabolic reprogramming in ccRCC has not been studied in detail so far. In addition, ccRCC can show a dense immune infiltration. Intriguingly, tumor infiltration with T cells can be negatively prognostic in RCC. This comprehensive study of the transcriptome, lipidome and immune infiltrate of ccRCC tumors elucidates the prognostic role of lipid-metabolic pathways and their possible interaction with tumor infiltrating T cells.

Methods

Freshly resected RCC tumors and adjacent kidney tissues and extracellular fluids were processed and subjected to mass-spectrometry based lipidomics and lipid staining (n = 36)

SUBMITTER: Simeth J 

PROVIDER: S-EPMC12444183 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature