Impact of clinical characteristics and genetic profiles on outcomes of allogeneic stem cell transplantation with sorafenib maintenance in <i>FLT3</i>-ITD acute myeloid leukemia patients: A multi-center, retrospective study.

ABSTRACT:

Objective

Acute myeloid leukemia (AML) patients with internal tandem duplications in the FMS-like tyrosine kinase 3 receptor gene (FLT3-ITD) receiving tyrosine kinase inhibitors maintenance after allogeneic hematopoietic stem cell transplantation (allo-HSCT) demonstrated improved survival outcomes, however, some still experienced relapse during the maintenance. This study aimed to explore risk factors which might be indicators for poor survival after allo-HSCT in this population.

Methods

We consecutively enrolled FLT3-ITD AML patients undergoing transplantation at three centers. By integrating genetic profiles with clinical information, we assessed their impact on transplant outcomes.

Results

A total of 196 patient were eligible in the analysis, among wh

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12444344 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature