A comparative transcriptomic analysis at single-cell resolution reveals acral melanoma features distinct from cutaneous melanoma.

ABSTRACT:

Objective

Acral melanoma (AM), a unique subtype prevalent in China, develops on the palms, soles, and nail beds. Despite its distinct clinical and pathological features compared to cutaneous melanoma (CM), the molecular basis underlying these differences remains poorly understood. This study aims to perform a comprehensive comparative transcriptomic analysis of AM and CM at the single-cell level to uncover key molecular distinctions.

Methods

We analyzed single-cell RNA sequencing (scRNA-seq) data from 39 AM patients and 18 CM cases. Single-cell transcriptomic profiling was used to compare tumor cell subpopulations and microenvironmental differences. Bioinformatics tools were employed for cell clustering, differential gene expression analysis, cell-cell communication network

SUBMITTER: Zhao H 

PROVIDER: S-EPMC12444355 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature