Circulating extracellular RNAs, myocardial remodeling, and elevated BMI in patients with acute coronary syndrome.

ABSTRACT:

Objective

Given the elevated mortality in individuals with acute coronary syndrome and increased adiposity, delineating the molecular mechanisms underlying obesity-associated adverse cardiac remodeling is critical for the identification of novel pathophysiological biomarkers and potential therapeutic targets. Circulating extracellular RNAs (ex-RNAs) regulate important biological processes and can serve as biomarkers of disease. This study aims to discover circulating extracellular RNAs (ex-RNAs) that serve as biomarkers of obesity-associated adverse cardiac remodeling in ACS survivors.

Methods

We analyzed extracellular RNA (ex-RNA) profiles in 296 survivors of acute coronary syndrome enrolled in the Transitions, Risks, and Actions in Coronary Events - Center for Outcomes Res

SUBMITTER: Tak KA 

PROVIDER: S-EPMC12444414 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature