Type I gamma phosphatidylinositol phosphate kinase i5 suppresses YAP1 signaling.

ABSTRACT: Dysregulation of the Hippo/Yes-associated protein (YAP) signaling pathway has been associated with several diseases, including cancer, neurological disorders, and cardiovascular conditions. However, the precise molecular mechanisms governing Hippo/YAP signaling are not fully understood, and additional regulators of this pathway need to be identified. Our research has identified type I gamma phosphatidylinositol phosphate kinase i5 (PIPKIγi5) as a regulator of Hippo/YAP signaling. PIPKIγi5 is a kinase responsible for synthesizing phosphatidylinositol-4,5-bisphosphate (PI4,5P₂). By directly interacting with YAP1, PIPKIγi5 prevents the nuclear translocation of YAP1, thereby suppressing YAP1-mediated gene transcription. Thus, PIPKIγi5 functions as a suppressor of YAP1-mediated signa

SUBMITTER: Ghosh C 

PROVIDER: S-EPMC12444467 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature