Liver-bone organoids reveal senescence-driven interorgan crosstalk.

ABSTRACT: The liver-bone axis plays a critical role in age-related diseases. However, current models inadequately capture its complex inter-organ communication. Here, we established novel, physiologically relevant senescent liver and bone organoid models using engineered bionic hydrogels combined with doxorubicin (DOX)-induced senescence. These models successfully recapitulated hallmark aging characteristics: bone organoids exhibited reduced mineralization accompanied by elevated senescence markers, and liver organoids demonstrated DNA damage along with structural deterioration. Notably, aged mouse serum effectively induced senescence in both organoid types, confirming the existence of systemic aging regulators. The platform demonstrated robust bidirectional crosstalk, with senescent liver organoid-

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12444486 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature