Mycolic Acid-like Lipids Act as Substrates for <i>Mycobacterium marinum</i> <i>melH</i>.

ABSTRACT: Mycobacterium tuberculosis (M. tuberculosis), the pathogenic bacterium that causes tuberculosis, has developed its own mechanism to evade defense mechanisms to counteract the lethal effects of reactive oxygen species (ROS) generated within host macrophages during infection. The melH gene present in Mycobacterium tuberculosis and Mycobacterium marinum plays an important role in reducing ROS generated during infection. The melH gene encodes an epoxide hydrolase. Bioinformatics data suggests that the encoded enzyme utilizes lipid substrates for its function. To identify potential physiological substrates of MelH in Mycobacterium marinum (M. marinum), we employed a lipid fractionation approach combined with liquid chromatography-mass spec

SUBMITTER: Chakraborti S 

PROVIDER: S-EPMC12444526 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature