Study on Antitumor Secondary Metabolites from <i>Euphorbia ebracteolata</i> Hayata: Structural Characterization, Network Pharmacology, Molecular Docking and <i>In Vitro</i>.

ABSTRACT: Euphorbia ebracteolata Hayata, a perennial herbaceous plant known as "langdu" in traditional Chinese medicine, utilizes its dried root for treating cancer, ascites, and edema. In this study, a structure-guided chemical investigation of E. ebracteolata led to the identification of 21 secondary metabolites. Notably, five of these were previously undescribed compounds, designated as euphebranones A-E, whose structures were elucidated through comprehensive spectroscopic analysis. Among these, euphebranones B-E were found to be unusual derivatives of ECBs. Given the traditional application of E. ebracteolata in cancer treatment, we screened these new compounds against a panel of tumor cell lines. Interestingly, (±)-euphebranone A, a racemic compound, demonstrated excellent

SUBMITTER: Xu NW 

PROVIDER: S-EPMC12444531 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature