Modulating Rheological Properties via Non-Cross-Linked Phase in Biphasic Hyaluronic Acid Fillers.

ABSTRACT: Hyaluronic acid (HA) based soft tissue augmentation materials are high-value-added products that have been used as filling materials in many areas such as the chin, face, and hands for many years. In our study, the synthesis methodology that utilizes a less toxic cross-linker to obtain stiffer gels with a high storage modulus (G') leads to much safer dermal fillers. For this purpose, citric acid (CA) was used as a green cross-linker. By altering the amount of CA, a series of non-cross-linked gels were prepared and reconstituted with a size-reduced cross-linked phase to prepare biphasic hyaluronic acid fillers with different mechanical and rheological characteristics. The effect of steam sterilization on the biphasic gels' physical properties was examined. No toxic waste was encountered aft

SUBMITTER: Buyukuysal OG 

PROVIDER: S-EPMC12444562 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature