Hydrothermal synthesis of Ag@Zn-salen MOF nanocomposite <i>via</i> a two-step method for ultrasensitive CA15-3 biosensing in breast cancer diagnostics.

ABSTRACT: Metal-organic frameworks (MOFs) integrated with noble metal nanoparticles offer transformative potential in biosensing, yet bimetal composites face persistent challenges, including inhomogeneous nanoparticle distribution and framework destabilization. Salen-based MOFs, prized for their thermal stability and tunable electronic properties, remain underexplored for bimetal systems despite their catalytic and plasmonic synergies. This study addresses the critical need for a synthesis strategy that ensures the uniform dispersion of plasmonic silver nanoparticles (Ag NPs) within a robust Zn-salen metal-organic framework (MOF) matrix while preserving structural integrity for biomarker detection applications. Conventional one-pot methods for bimetal MOFs often result in Ag NP aggregation (>200 nm)

SUBMITTER: Eldin AG 

PROVIDER: S-EPMC12444622 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature