Serum sodium trajectories impact clinical outcomes in extracorporeal resuscitation of cardiac arrest: A multicenter retrospective cohort study.

ABSTRACT:

Background

Dysregulation of serum sodium levels subsequent to out-of-hospital cardiac arrest (OHCA) has the potential to influence neurological outcomes. The patterns of sodium correction remain inadequately studied in individuals undergoing extracorporeal cardiopulmonary resuscitation (ECPR). This investigation aimed to elucidate the correlation between the trajectories of serum sodium concentration and clinical outcomes in patients subjected to ECPR.

Methods

This study was a secondary analysis of the SAVE-J II study, a retrospective multicenter registry targeting OHCA adult patients resuscitated with extracorporeal membrane oxygenation in Japan. Using the k-means clustering method, patients were categorized into four clinically relevant clusters: normal range, corrected hy

SUBMITTER: Amemiya Y 

PROVIDER: S-EPMC12444628 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature