Ultrasmall Manganese Oxide Nanoparticles as Contrast Agents for T₁‑T₂ Dual-Modal Magnetic Resonance Imaging.

ABSTRACT: Recently, Manganese oxide (MnO) nanoparticles have garnered considerable research interest due to their high applicability in Magnetic Resonance Imaging (MRI), leveraging their light-enhancing properties. In present work, ultrasmall and monodisperse MnO nanoparticles were synthesized via thermal decomposition and subsequently coated with poly-(maleic anhydride-alt-1-octadecene) (PMAO) to stabilize the colloidal dispersion and optimize image contrast. The impact of the surfactants (oleic acid (OA) and oleylamine (OLA) surfactants with ratio 1:1) and the reaction temperature on nanoparticle characteristics was systematically studied. Optimal synthesis conditions, including a surfactant concentration of 600 mM for both OA and OLA and a reaction temperature of 320 °C, yielded monodisper

SUBMITTER: Thi Nguyen LN 

PROVIDER: S-EPMC12444676 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature