Physico-biochemical Properties of Chitosan-poly(<i>N</i>‑[3-(dimethylaminopropyl)] methacrylamide) Copolymers Synthesized as siRNA Carrier Biomaterials.

ABSTRACT: In the present study, poly-(N-[3-(dimethylaminopropyl)] methacrylamide) (PDMAPMAAm) grafts/blocks and chitosan (Cs) backbone bearing tertiary and primary amine groups, respectively, were copolymerized by the conventional free-radical solution method to prepare novel nonviral cationic carriers covering a pH range between 4.0 and 9.0. All of the chain parameters calculated by experimental and theoretical methods indicated that with increasing KPS concentration, the structures of Cs-PDMAPMAAm (Cs/D) copolymers changed from graft to block copolymer. The constants of the Mark-Houwink-Sakurada (MHS) equation K and a were also determined to calculate the molecular weights of synthesized PDMAPMAAm and its hydrolyzed grafts. For physico-biochemical properties, FTIR, GPC, and

SUBMITTER: Simsek C 

PROVIDER: S-EPMC12444683 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature