The Role of Aerosol Liquid Water in Droplet-Assisted Ionization Mass Spectrometry.

ABSTRACT: Chemical analysis of aerosols by mass spectrometry is challenging because aerosols contain little mass and have complex compositions. Consequently, relatively few approaches allow online molecular (i.e., minimal fragmentation) analysis on aerosols, particularly for ultrafine (<100 nm) particles. Droplet-assisted ionization (DAI) mass spectrometry is a promising and straightforward approach for aerosol molecular analysis. In DAI, liquid aerosol droplets are delivered directly to the mass spectrometer inlet, where the droplets break up and form molecular ions similar to those observed in electrospray ionization. This study explores how aerosol liquid water, serving as a matrix, controls ion generation in DAI for systems spanning simple binary and more complex ternary ones. The results demons

SUBMITTER: Harrison J 

PROVIDER: S-EPMC12444750 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature