Dominance of high-risk clones ST2 and ST571 and the diversity of resistance islands in clinical <i>Acinetobacter baumannii</i> isolates from Hanoi, Vietnam.

ABSTRACT: Multidrug-resistant Acinetobacter baumannii poses a significant threat to hospital environments worldwide, including Vietnam. In this study, we conducted whole-genome sequencing on 30 clinical A. baumannii isolates from Hanoi to explore their genomic diversity, antibiotic resistance determinants, virulence factors and mobile genetic elements. Phylogenetic analyses, utilizing both SNP-based and multilocus sequence typing-based approaches, revealed that the isolates clustered into various sequence types (STs). Among these, ST2 and ST571 emerged as the dominant high-risk clones. The ST2 isolates exhibited a wide range of resistance genes, such as bla _OXA-23, mph(E), msr(E) and armA. Additionally, they contained mobile genetic elements, incl

SUBMITTER: Nghiem MN 

PROVIDER: S-EPMC12444785 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature