Exploration of Fluorinated Pyrazolidine-3,5-Diones for Positron Emission Tomography Imaging of the P2Y₁₂ Receptor in the Central Nervous System.

ABSTRACT: The purinergic receptor P2Y₁₂ (P2Y₁₂R) has emerged as a promising biomarker for selectively imaging the anti-inflammatory phenotype of microglia. Developing positron emission tomography (PET) tracers for this target is an active area of research, as imaging of specific microglial phenotypes can provide valuable insights into their dynamics in neuroinflammation. A key challenge is identifying high affinity P2Y₁₂R ligands with optimal properties for targeting this receptor in the central nervous system (CNS). Herein, the synthesis and evaluation of a series of fluorinated pyrazolidine-3,5-dione derivatives are conducted as potential P2Y₁₂R PET tracers, designed based on a literature compound with promising physicochemical properties for brain perme

SUBMITTER: Steen EJL 

PROVIDER: S-EPMC12444843 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature