Gastrointestinal Barrier Disruption in Post-COVID Syndrome Fatigue Patients.

ABSTRACT:

Background

Post-COVID Syndrome (PCS) is the term for a condition with persistent symptoms in a proportion of COVID-19 patients after asymptomatic, mild, or severe disease courses. Numbers vary, but the current estimate is that after COVID-19 approximately 10% develop PCS. The aim of our study was to evaluate the impact of SARS-CoV-2 infection on the gastrointestinal (GI) tract and associations with the development of PCS with fatigue, post-exertional malaise (PEM), orthostatic dysregulation, autonomous dysregulation, and/or neurocognitive dysregulation.

Methods

By combining medical record data from a prospective observational study with symptom analysis before, during, and after SARS-CoV-2 infection, we aimed to identify potential risk factors and predictive markers for PCS.

SUBMITTER: Rohrhofer J 

PROVIDER: S-EPMC12444858 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature