IL17RA and IL21R polymorphisms influence type 1 diabetes predisposition and autoimmune phenotypes.

ABSTRACT:

Introduction

Although interleukin receptors have been implicated in various autoimmune diseases, their role in type 1 diabetes (T1D) remains underexplored and occasionally inconsistent. To evaluate the impact of polymorphisms in genes encoding the interleukin receptors IL-21R and IL-17RA on T1D susceptibility and other autoimmune manifestations, we analyzed 639 patients with T1D and 653 healthy controls.

Methods

Selected variants in IL17RA (n=4), IL21R (n=4), were genotyped using the VeraCode GoldenGate assay (Illumina, USA). Autoantibodies were assessed by radioimmunoassay, ELISA, and a radiolabeled iodine receptor assay.

Results

Two IL17RA variants were significantly associated with T1D: the rs2241049G allele was linked to increased susceptibility (OR=1.42; p

SUBMITTER: Semzezem C 

PROVIDER: S-EPMC12444888 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature