Stroke-heart syndrome and risk of incident dementia among patients with first-ever ischemic stroke: A territory-wide population-based cohort study.

ABSTRACT:

Introduction

The risk of dementia in patients with ischemic stroke and early cardiovascular complications (i.e., stroke-heart syndrome [SHS]) remains underexplored.

Methods

Patients with first-ever ischemic stroke in Hong Kong between 2005 and 2020 were included. Multivariable Fine-Gray competing risk analysis was performed after 1:1 propensity score matching to evaluate the association between SHS and the risk of dementia.

Results

Of the 130,605 included patients with ischemic stroke, 12,696 (9.7%) patients developed SHS. Patients with SHS had a 19% increased risk of dementia compared to those without SHS at 1 year post-stroke, driven mainly by vascular dementia. This increased risk gradually declined and became non-significant after 3 years post-stroke. Appropriate

SUBMITTER: Tsang CTW 

PROVIDER: S-EPMC12444938 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature