Periventricular diffusivity reflects APOE ε4-modulated amyloid accumulation and cognitive impairment in the Alzheimer's disease continuum.

ABSTRACT:

Introduction

Altered glymphatic-related fluid dynamics are increasingly recognized as a feature of Alzheimer's disease (AD). We generalized an established diffusion imaging framework to quantify periventricular diffusivity (PVeD), hypothesizing that fast diffusion signals in the periventricular region can reflect amyloid beta (Aβ) deposition across the AD continuum.

Methods

Participants from two multi-site cohorts (n = 440 and 414), comprising cognitively unimpaired individuals, those with mild cognitive impairment, and patients with AD, were included. We tested and validated the association of PVeD with Aβ burden and core AD characteristics.

Results

Lower PVeD was extensively associated with greater Aβ burden, neurodegeneration, cognitive impairment, and clinical sev

SUBMITTER: Chen CL 

PROVIDER: S-EPMC12444947 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature