Genome-wide association study meta-analysis uncovers novel genetic variants associated with olfactory dysfunction.

ABSTRACT:

Background

Olfactory dysfunction is among the earliest signs of many age-related neurodegenerative diseases and has been associated with increased mortality in older adults; however, its genetic basis remains largely unknown. Therefore, here we aimed to elucidate its genetic architecture through a genome-wide association study meta-analysis (GWMA).

Methods

This GWMA included the participants of European ancestry (N = 22,730) enrolled in four different large population-based studies followed by a multi-ancestry GWMA including participants of African ancestry (N = 1,030). Olfactory dysfunction was assessed using a 12-item smell identification test.

Results

GWMA revealed a novel genome-wide significant locus (tagged by single nucleotide polymorphism rs11228623 at the 11q

SUBMITTER: Imtiaz MA 

PROVIDER: S-EPMC12445039 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature