Characterization of gut microbiota and metabolites in individuals with constipation-predominant irritable bowel syndrome.

ABSTRACT:

Objective

Constipation-predominant irritable bowel syndrome (IBS-C) is a prevalent functional gastrointestinal disorder with an incompletely understood pathogenesis. Recent studies have found that gut microbiota may contribute to its development. This study aimed to characterize the gut microbiota and associated metabolites in individuals with IBS-C to investigate potential pathogenic mechanisms.

Methods

A total of 22 individuals diagnosed with IBS-C and 22 healthy controls were recruited at the First Hospital of Tsinghua University between January and December 2023. Stool samples were collected and subjected to metagenomic and metabolomic analyses to assess microbial composition and metabolic profiles. Bioinformatic analyses were employed to integrate and interpret the data

SUBMITTER: Wang YL 

PROVIDER: S-EPMC12445051 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature