Colorectal cancer-associated <i>Streptococcus gallolyticus</i>: a hidden diversity expose.

ABSTRACT: Streptococcus gallolyticus subsp. gallolyticus (SGG) is a bacterial pathogen implicated in bacteremia and endocarditis and is often associated with colon tumors in elderly individuals. The development of colorectal cancer (CRC) has been linked to intestinal dysbiosis, characterized by increased proportions of SGG and other intestinal microbes. In this study, we present the complete nucleotide sequence of five novel clinical isolates of SGG associated with colorectal cancer, revealing unexpected genetic diversity. Sequencing an additional 30 SGG clinical isolates provided a more comprehensive description of this genetic diversity. We did not identify a pathogenicity island specific to CRC-associated SGG isolates. Most of these human-derived <

SUBMITTER: Perichon B 

PROVIDER: S-EPMC12445087 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature