<i>Staphylococcus aureus</i> phenol-soluble modulins have dispersal and anti-aggregation activity towards corynebacteria.

ABSTRACT: Staphylococcus aureus is a common upper respiratory tract (URT) pathobiont with high carriage rates in the upper airway disease chronic rhinosinusitis (CRS). CRS is associated with increased prevalence and abundance of S. aureus, and S. aureus-secreted toxins are implicated in CRS pathogenesis. Conversely, in CRS disease, the abundance of non-pathogenic commensal species has been observed to decline, leading to microbial dysbiosis that contributes to persistent inflammation. Here, we investigated possible mechanisms S. aureus could employ to outcompete commensal organisms and contribute to establishing the S. aureus-dominant microbiome found in individuals with CRS. We performed a targeted screen to identify S. aureus-secreted factors that affect t

SUBMITTER: Huffines JT 

PROVIDER: S-EPMC12445096 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature