Identification of gene targets regulated by the IclR-like regulator SL1344_3500 in <i>Salmonella</i> Typhimurium.

ABSTRACT: Transcriptional regulation of metabolic operons is important for optimal carbohydrate use and for mitigating the accumulation of toxic intermediates. Here, we characterize SL1344_3500, encoding a putative IclR-like regulator in Salmonella enterica Typhimurium. We present genetic and transcriptional evidence that it regulates the expression of two neighboring operons, one designated here as xynABC, enables utilization of xylonate as a sole carbon source. Furthermore, our findings indicate that SL1344_3500 is important for luminal growth in several mouse models, exerting its effects through the suppression of the xynABC operon. Based on the observation that the ΔSL1344_3500 deletion can be stably complemented in vivo, we developed a plasmid st

SUBMITTER: Andersen TB 

PROVIDER: S-EPMC12445098 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature