Objective physical activity and Alzheimer's disease burden in the population-based Rotterdam Study.

ABSTRACT:

Introduction

Physical activity is linked to lower dementia risk, but its connection to Alzheimer's disease (AD) pathology remains uncertain. This study examined the relationship between objectively measured physical activity and early AD biomarkers in cognitively unimpaired adults.

Methods

Accelerometer-measured physical activity and plasma AD biomarkers (beta-amyloid [Aβ]42/Aβ40, p-tau217) were assessed in 242 participants (age = 63.37 [54-79] years) of the population-based Rotterdam Study. Cortical Aβ was assessed via ¹⁸F-florbetaben positron emission tomography (PET) 7 years later. Robust regression assessed the relationship between physical activity, plasma AD biomarkers, and Aβ PET burden, while compositional analysis examined how the time-use composition rel

SUBMITTER: Nguyen Ho PT 

PROVIDER: S-EPMC12445197 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature