Disrupted Brain Structure-Function Coupling and Its Mediating Effects on the Associations Between Cerebral Small Vessel Disease Burden and Cognitive Dysfunction.

ABSTRACT:

Aims

We aimed to specify relationships among cerebral small vessel disease (CSVD) burden, cognitive dysfunction, and brain structure-function coupling changes.

Methods

A total of 108 patients with mild CSVD burden (CSVD-m), 53 patients with severe CSVD burden (CSVD-s), and 76 healthy controls (HC) were included in this study. The ratio of regional homogeneity (ReHo) or amplitude of low-frequency fluctuation (ALFF) to gray matter volume (GMV) was calculated as an indicator of voxel-wise structure-function coupling.

Results

Significantly decreased or increased ReHo-GMV and ALFF-GMV coupling values in patients with severe CSVD burden were primarily found in several brain regions, and the disrupted structure-function coupling in the right putamen mediated the relationship

SUBMITTER: Wang N 

PROVIDER: S-EPMC12445204 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature