Targeting long non-coding RNA <i>MALAT1</i> preserves endothelial cell integrity and protects against kidney fibrosis.

ABSTRACT: Loss of integrity of the capillary network is directly associated with the development of kidney fibrosis resulting in chronic kidney disease. Here, we characterized long non-coding RNAs (lncRNAs) in endothelial cells (ECs) during the development of kidney fibrosis. Using a murine EC lineage-tracing model, we observed expression of the conserved lncRNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) to be elevated in ECs upon kidney injury; either by ischemia-reperfusion injury or by unilateral ureteral obstruction (UUO). In addition, we found elevated MALAT1 expression in the kidney and circulation of patients with fibrotic kidney diseases. Pharmacological intervention of Malat1 initiated protection against fibrosis in the UUO model, illustrated by a m

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC12445227 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature