Transcriptomic profiles of susceptibility and resilience to stress in the amygdala and hippocampus of male rats.

ABSTRACT: Traumatic experiences elicit a wide range of cognitive responses in both humans and animals, leading to diverse outcomes such as enhanced performance, cognitive impairment, or the development of mood and anxiety disorders like posttraumatic stress disorder (PTSD). A key challenge in understanding these varied responses is to decipher the underlying biological mechanisms that contribute to individual variability in trauma resilience or susceptibility. The purpose of this study was to elucidate the molecular bases for these differences, focusing on the amygdala and hippocampus-brain regions integral to stress responses. We exposed adult, male rats to an acute, severe stressor and profiled persistent anxiety-like behavior outcomes 7 days later. We investigated the transcriptional signatures i

SUBMITTER: Long KLP 

PROVIDER: S-EPMC12445234 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature