Activatable companion theranostics for dual-modality imaging-escorted pyroptosis-propelled synergistic cancer therapy.

ABSTRACT: Companion diagnostics (CDx) plays a pivotal role in precision medicine for cancer treatment. However, conventional CDx are often limited by their inability to provide real-time monitoring of cancer progression and therapeutic responses. Herein, we develop a dual-modality imaging-based companion theranostic (CTx) nanoplatform (LET-Cl@GOx), which integrates activatable photoacoustic (PA) and fluorescence (FL) imaging to enable the enhanced diagnostic accuracy and real-time therapeutic feedback, while demonstrating cascade-amplified photothermal/starvation synergistic therapy. The LET-Cl@GOx is designed by the assembly of glucose oxidase (GOx) with a pH-activatable near-infrared (NIR) dye (LET-Cl), enabling the turn-on of PA/FL imaging within the acidic tumor microenvironment (TME). The dynam

SUBMITTER: Wan Y 

PROVIDER: S-EPMC12445235 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature