Risk and temporal trends of heart failure subtypes in rheumatoid arthritis.

ABSTRACT:

Objective

Evaluate the risk and temporal trends of heart failure (HF) with preserved (HFpEF) and reduced ejection fraction (HFrEF) in rheumatoid arthritis (RA).

Methods

We performed a retrospective, matched cohort study using Veterans Health Administration (VHA) administrative and health record data from 2000 to 2019. Patients with RA were matched up to 10 non-RA controls on age, sex, and VHA enrollment year. Incident HF and HF-related death were queried, classifying HFpEF and HFrEF using left ventricular EF data from a validated natural language processing tool. HF risk was evaluated using conditional Cox regression, adjusting for demographics, body mass index, smoking, rurality, healthcare utilization, and comorbidity burden. Trends in HF risk were evaluated, stratifying m

SUBMITTER: Johnson TM 

PROVIDER: S-EPMC12445436 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature