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Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda.

ABSTRACT:

SUBMITTER: Kakuru A 

PROVIDER: S-EPMC12445490 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature

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Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda.

Kakuru Abel A   Kizza Jimmy J   Aguti Miriam M   Adrama Harriet H   Ategeka John J   Olwoch Peter P   Nakalembe Miriam M   Nankabirwa Joaniter I JI   Opira Bishop B   Ozarslan Nida N   Ranjit Anju A   Dela Cruz Erin E   Clark Tamara D TD   Roh Michelle E ME   Gaw Stephanie L SL   Jagannathan Prasanna P   Rosenthal Philip J PJ   Kamya Moses R MR   Dorsey Grant G  

PLoS medicine 20250918 9

<h4>Background</h4>To mitigate adverse consequences of malaria in pregnancy, the World Health Organization recommends intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine. However, the effectiveness of IPTp with sulfadoxine-pyrimethamine has been threatened by widespread Plasmodium falciparum resistance, especially in East and Southern Africa. For IPTp, dihydroartemisinin-piperaquine has shown superior antimalarial effects compared to sulfadoxine-pyrime  ...[more]

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